СРАВНИТЕЛЬНОЕ ИЗУЧЕНИЕ БИОЭЛЕКТРИЧЕСКОЙ АКТИВНОСТИ СЕНСО-МОТОРНОЙ КОРЫ ПРИ ИНТОКСИКАЦИИ СТИРОЛОМ У КРОЛИКОВ РАЗНОГО ВОЗРАСТА

control (p<0.05). Levels of CRP and fibrinogen in control was 2.3±0.09 
mg/l and 1.1±0.17 g/l, where COPD was -18.8 ± 0,99 g/l and 4.1 ±0,14 
g/l. Young's Modulus of neutrophils in COPD was higher than the control 
group at 2.5 times. The stiffness of the membranes of neutrophils in 
the control amounted 15,29±0,05 kPa; in patients with COPD it was 38,79±0,32 kPa (p<0.05). The adhesion force of neutrophils in COPD 
patients was higher than in the control group in 5,52 times; in the 
control it was 0.076± 0,0002 nN, in the group of COPD patients it was 0.42 ± 0,005 nN (p<0.05). Correlation analysis revealed a close 
relationship of Young's modulus with the level of CRP (r=0, 59, p<0.05) 
and fibrinogen (r =0, 91, p<0.05); also the adhesive force with CRP 
levels (r=0, 48, p<0.05) and fibrinogen (r=0, 92, p<0.05). 

Conclusions: COPD patients monitoring showed increase in the 

number of circulating neutrophils, CRP levels, fibrinogen, adhesion 
force and stiffness of the neutrophils membranes. The correlation 
analysis showed a close direct correlation of neutrophils viscoelastic 
properties with the level of CRP and fibrinogen.

References.
1.Blidberg  K., Palmberg L., Jameet A. Adhesion molecule sin 
subjects with COPD and healthynon-smokers: a cross sectional 
parallel group study. Respir. Res. 2013;14:47
2.Emiel F.M. Wouters. Local and Systemic Inflammation in Chronic 
Obstructive Pulmonary Disease. Proc. Am. Thorac 2005;2: 26–33.
3.Global Initiative for Chronic Obstructive Lung Disease (GOLD). 
Global strategy for diagnosis, management, and prevention of 
chronic obstructive pulmonary disease. NHLBI/WHO workshop report. 
Last updated 2014. www.goldcopd.org/. 
4.Noguera A., Batle S., Miralles C. et al. Enhanced neutrophil 
response in chronic obstructive pulmonary disease. Thorax 2001; 56
(6): 432–437.
5.Roca-Cusachs P., Almendros I., Sunyer R. et al. Rheology of 
Passive and Adhesion-Activated Neutrophils Probed by Atomic Force 
Microscopy. Biophysical Journal 2006; 91:3508–3518.
DOI:10.12737/12318

СРАВНИТЕЛЬНОЕ ИЗУЧЕНИЕ БИОЭЛЕКТРИЧЕСКОЙ АКТИВНОСТИ СЕНСОМОТОРНОЙ КОРЫ ПРИ ИНТОКСИКАЦИИ СТИРОЛОМ У КРОЛИКОВ РАЗНОГО 

ВОЗРАСТА

У.Ф. Гашимова, Х.Ю. Исмайлова, Е.О.Байрамова

Институт физиологии им.А.И.Караева Национальной Академии Наук 

Азербайджана, Баку

bayramova.physiolog@gmail.com

На фоне хронической затравки стиролом кроликов разного возраста 

ослабляется функциональное состояние сенсомоторной коры, выражающееся в 
ускорении 
возрастных 
изменений 
амплитудно-частотных 
показателей 

биоэлектрической активности.
Ключевые слова: сенсомоторная кора, стирол, биоэлектрическая активность