ЛИЧНОСТНЫЕ ОСОБЕННОСТИ И УСПЕШНОСТЬ УЧЕБНОЙ ДЕЯТЕЛЬНОСТИ СТУДЕНТОВ
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Издательство:
НИИ ноpмальной физиологии им. П.К. Анохина
Автор:
Дегтярев Владимир Павлович
Год издания: 2015
Кол-во страниц: 4
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in n. basalis magnocellularis neurotoxic fragment Aβ25-35 [2]. Rats were divided into 5 groups (each consisting of six animals): intact animals (I), sham-operated animals (SO), rats that were bilaterally admistered with the neurotoxic fragment of Аβ25–35, which were intranasally administered with 10 μl of distilled water 1 h after surgery (Аβ25–35+H2O), animals that were intranasally administered with an aqueos solution of AB-Glu obtained from immunized rabbits at a dose of 300 μg/kg (Аβ25– 35+AB-Glu) according to the previous scheme, animals that were intranasally administered in the same way with an aqueos solution of rabbit γ-globulin obtained from the intact rabbits at a dose of 300 μg/kg (Аβ25–35+ γ-globulin). Gene expression was analyzed by real-time PCR in prefrontal cortex and hippocampus samples after 3 days after operation. Mathematical processing of relative gene expression was performed by non-parametric statistics (p <0,05) with Me (Q1; Q3) (reference genome was Actb). RESULTS. The prefrontal cortex cell transcriptome of the rats administered -35 changed towards the programmed cell death. The expression of all studied genes increased compared to the intact animals. Glutamate antibodies in dose 300 µg/kg one hour after the brain damage significantly reduced the increased expression of Aifm 1, -35. The obtained results appear to be evidence of the defensive effect of glutamate antibodies in gene regulation of key apoptosis genes. The molecular mechanism of action of AT-Glu on gene expression Aifm1, Bax, Casp3, Dffb Parp1 at present remains insufficiently known, but one can assume that one of the possible ways of AT-Glu participate in reducing the neuron death of the hippocampus and prefrontal cortex upon administration of the neurotoxin Aβ25-35 in the Meynert nucleus is mediated by their effect on the level of glutamate and NMDA-receptor activity. REFERENCES 1. Gorbatov V.Yu., Trekova N.A., Fomina V.G., Davydova T.V., Byull. Eksp. Biol. Med., 149, No. 6, 28-30 (2010). 2. Harkany T., O’Mahony S., Kelly J.P. et all // Behav. Brain. Res., 90. – 133-145. (1998). DOI:10.12737/12336 ЛИЧНОСТНЫЕ ОСОБЕННОСТИ И УСПЕШНОСТЬ УЧЕБНОЙ ДЕЯТЕЛЬНОСТИ СТУДЕНТОВ В.П. Дегтярев Кафедра нормальной физиологии МГМСУ degtyarev-phyz@mail.ru Ключевые слова: успешность обучения, личностные свойства, модулирующая система мозга, висцеральные функции, психо-эмоциональное напряжение.