INVOLVEMENT OF THE ENDOCANNABINOID SYSTEM IN ADDICTIVE BEHAVIOR

synthesis of bile acids and effective transportation of sterols in the bile [4]. Higher frequency of occurrence of an insertion insertional deletion polymorphism of angiotensin i converting enzyme gene in buryat ethnic group teenagers in comparison with the russian one revealed. Intensity of processes of a lipids peroxidation at buryat teenagers with essential arterial hypertension is much lower, than in russians. It was revealed that course of such diseases as t1dm, essential arterial hypertension, chronic obstructive pulmonary disease, cardiovascular disease are more favorable for buryats, and adverse-tuberculosis, endocrine infertility, complicated pregnancy, glaucoma, bones and joints diseases are more complicated. Proposed to take into account the ethnic characteristics of genome, metabolome, microbiome, reproduction, epidemiology and pathogenesis of diseases to develop personalized approach for diagnosis, prevention and treatment of certain pathologies, as well as to use this information for the formulation of socio-economic and health forecasts to improve healthcare system. Investigations supported by president of russia grant for "the leading school of sciences" of № - 5646. 2014.7.
REFERENCES
1.   Dedov II, Kolesnikova LI, Ivanova ON et al. Polymorphism of genes of HLA of a class II and CTLA4 in healthy Buryats and patients with diabetes of 1 type in the Buryat Republic // Diabetes. 2006. № 1. P. 28.
2.   Report of the World Conference against Racism, Racial Discrimination, Xenophobia and Related Intolerance. Durban, 31 August - 8 September 2001, p.49-50
3.   Kolesnikova LI, Suturina LV, Labygina AV et al. Violations of reproductive health and reproductive potential in modern conditions of Eastern Siberia // Bulletin VSNC SO RAMN. 2007. № 2. P. 41-43.
4.   Manchuk VT, Nadtochy LA State of health of radical and small peoples of the North, Siberia and Far East, feature of formation of pathology. Krasnoyarsk: B. and., 2012. 338 p.
5.   Kolesnikova LI, Darenskaya MA, Grebenkina LA et al. Activity of lipid peroxidation in infertile women from different populations // Bulletin of Experimental Biology and Medicine. 2012. Vol. 154. № 2. P. 203-205.
DOI:10.12737/12269





                INVOLVEMENT OF THE ENDOCANNABINOID SYSTEM IN ADDICTIVE BEHAVIOR




Maldonado Lopez Rafael

Laboratory of Neuropharmacology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, C/Dr. Aiguader, 88, 08003 Barcelona, Spain
rafael.maldonado@upf.edu

     The involvement  of the endocannabinoid  system in drug addiction
was initially studied by the use of compounds with different affinities

17

for each cannabinoid receptor or for the proteins involved in endocannabinoids inactivation. The generation of genetically modified mice with selective mutations in these endocannabinoid system components has now provided important advances in establishing their specific contribution to drug addiction. These genetic tools have identified the particular interest of CB1 cannabinoid receptor and endogenous anandamide as potential targets for drug addiction treatment. Novel genetic tools will allow determining if the modulation of CB2 cannabinoid receptor activity and 2-arachidonoylglycerol tone can also have an important therapeutic relevance for drug addiction.
     References
1. Flores A, Maldonado R,  Berrendero F. The hypocretin/orexin receptor   1 as a novel target to  modulate cannabinoid reward. Biol Psychiatry.
   2014 Mar 15;75(6):499-507. doi: 10.1016/j.biopsych.2013.06.012. Epub 2013 Jul 26.
2. Flores A, Maldonado R, Berrendero F. Cannabinoid-hypocretin crosstalk in the central nervous system: what we know so far. Front Neurosci. 2013 Dec 20;7:256. doi: 10.3389/fnins.2013.00256.
3. Maldonado R1, Robledo P, Berrendero F. Endocannabinoid system and drug addiction: new insights from mutant mice approaches. Curr Opin Neurobiol. 2013     Aug;23(4):480-6. doi:    10.1016/j.conb.2013.02.004.
   Epub 2013 Mar 13.
4. Maldonado R, Berrendero F, Ozaita A,  Robledo P.  Neurochemical basis
   of cannabis addiction. Neuroscience. 2011 May 5;181:1-17.
5. Maldonado R, Berrendero F. Endogenous cannabinoid and opioid systems
   and their role in nicotine addiction. Curr Drug Targets. 2010 Apr;11(4):440-9. Review.
DOI:10.12737/12271





                AMYLOID SPECIES, NEUROCHEMISTRY AND AUTOIMMUNITY LINKED TO PARKINSONIAN-LIKE SYMPTOMS




R. D. E. Sewell¹, M. A. Gruden²

¹Cardiff School of Pharmacy & Pharmaceutical Sciences, Cardiff University, Cardiff, CF10 3NU., UK,
²P. K. Anokhin Research Institute of Normal Physiology, Moscow, 125009, Russia

     Parkinson’s disease (PD) is a neurodegenerative disorder in which a-synuclein (a-syn) toxic aggregates specifically from the synuclein protein family and neurotransmitters such as dopamine (DA) play a critical role. a-Syn itself is known to be natively unstructured but it is in equilibrium with subpopulations of more compact structures and it is these aggregates that are thought to be linked to amyloid formation. In this respect, there are elevated autoantibody serum titers to a-synuclein monomers, oligomers and fibrils which appear to reach a zenith in Parkinsonian patients at the 5-year disease stage (Gruden et al., 2011). We have also demonstrated that in vitro, a-syn can form


18